DelveInsight has recently published a report on “Resminostat Market Forecast Report” providing an in-depth analysis of the Resminostat market analysis and forecasts up to 2032 in the seven major markets (7MM) (i.e. the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan. The comprehensive report provides an analysis of Resminostat market potential and market share analysis in the Cutaneous T-cell lymphoma therapeutics space across the 7MM from 2019 to 2032.
The report also helps you to understand the Resminostat clinical and commercial developments along with parameters like the drug’s Mechanism of Action (MOA), Route of Administration (ROA), dosage, and special designations.
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Resminostat Drug Summary
Resminostat is a potent inhibitor of class I, IIb, and IV HDACs, including a pronounced activity against HDAC6. In pharmacology studies, resminostat dose-dependently inhibited HDACs and induced acetylation of histone and non-histone proteins, resulting in changes in gene expression levels in tumor cells and the deregulation of pathways involved in cell differentiation, such as WNT signaling. Changes in cell differentiation are very often the cause of tumor progression, metastasis, and acquired resistance to anti-cancer treatment. Resminostat is currently being investigated in a pivotal study in cutaneous T-cell lymphoma (CTCL) as a maintenance treatment by 4SC in Europe and by Yakult Honsha in Japan.
Resminostat has demonstrated effects in CTCL-derived cell lines, stabilizing less advanced malignantly transformed T cells or even reversing advanced stages of disease to less advanced stages, which indicates a unique potential in both maintenance therapy as well as in the treatment of progressive disease.
In addition to these important effects on the differentiation of tumor cells, resminostat also increases the immunogenicity of tumors by enhancing natural killer (NK) cell recognition and killing, increasing expression and presentation of tumor-associated antigens (that support T-cell functions), and reducing unspecific immunosuppressive mechanisms.
In vivo, resminostat has demonstrated significant anti-tumor activity in various human xenograft mice tumor models, and in combination with established therapies—such as irinotecan or sorafenib – generated additive, synergistic anti-tumor effects.
In January 2023, 4SC AG announced that its pre-authorization eligibility request to the European Medicines Agency (EMA) for resminostat in cutaneous T-cell lymphoma had been accepted.
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Cutaneous T-cell lymphoma Market Outlook and Forecast
“Cutaneous T-cell lymphoma Market Insights, Epidemiology and Market Forecast 2032” report delivers an in-depth understanding of Cutaneous T-cell lymphoma, historical and forecasted epidemiology as well as the Cutaneous T-cell lymphoma market trends in the United States, EU4 (Germany, Spain, Italy, and France), and the United Kingdom, and Japan. It also covers the key companies and emerging therapies in the Cutaneous T-cell lymphoma therapeutics landscape.
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