DelveInsight’s, “Toll-Like Receptor 4 (TLR-4) Agonist Pipeline Insight, 2024,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Toll-Like Receptor 4 (TLR-4) Agonist pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

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Key Takeaways from the Toll-Like Receptor 4 (TLR-4) Agonist Pipeline Report

• In August 2024:- Jonsson Comprehensive Cancer Center- The main purpose of this study is to evaluate the most effective immunotherapy vaccine components in patients with malignant glioma. Teh investigators previous phase I study (IRB #03-04-053) already confirmed that this vaccine procedure is safe in patients with malignant brain tumors, and with an indication of extended survival in several patients.
• In July 2024:- Baylor College of Medicine- This study evaluates the efficacy, safety and immunogenicity of different formulations of the Na-GST-1 hookworm vaccine using a controlled human hookworm infection model in healthy, hookworm-naive adults.
• DelveInsight’s Toll-Like Receptor 4 (TLR-4) Agonist pipeline report depicts a robust space with 10+ active players working to develop 10+ pipeline therapies for Toll-Like Receptor 4 (TLR-4) Agonist treatment.
• The leading Toll-Like Receptor 4 (TLR-4) Agonist Companies such as Eisai, Akaza Bioscience, OPNT-003, GeNeuro, MN-166 (ibudilast), Orexo, and others.
• Promising Toll-Like Receptor 4 (TLR-4) Agonist Therapies such as P2PAR-100, SBT8230, RG 6115, TransCon TLR 7/8 agonist, NKTR-262, BNT411, BO112, PrEP-001, BDB001, Cobitolimod, Tilsotolimod, SD 101, Lefitolimod, Vesatolimod, Vidutolimod, Rintatolimod, DUET 01, NJB 834, INNA 051, Glycopyranosyl lipid adjuvant, G 100, TARA-002, RO 7020531, Resiquimod,  BDC 1001, SHR 2150, LHC 165, PRX 034, ELI 002, IDX 9059, Entolimod, and others.

 

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Toll-Like Receptor 4 (TLR-4) Agonist Emerging Drugs Profile

 

• E-5564: Eisai

E-5564 (Eritoran) is a TLR (Toll-Like Receptor) 4 antagonist created with natural product organic synthesis technology. It is a structural analogue of Lipid A which is an activator of endotoxins of bacteria. It is expected to suppress inflammation and increasing in severity caused by COVID-19 by inhibiting the activation of TLR4, which is found in the most upstream position of various cytokine gene expression signaling that causes the cytokine-storm. Development is in collaboration with GCAR (Global Coalition for Adaptive Research).

It is currently in Phase III stage of development and is being developed by Eisai.

• TAK-242: Akaza Bioscience

TAK-242 acts as inhibitor of Toll-like receptor 4. Akaza Bioscience is preparing to run a Phase II study of TAK-242, a novel immunological therapy. This pan-European study aims to investigate the safety and efficacy of TAK-242, as measured by changes in key biomarkers and 28-day survival rates. The trial will be a randomised, double-blind, placebo-controlled study in patients with Grade 1 or 2 ACLF.

 

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Toll-Like Receptor 4 (TLR-4) Agonist pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration.

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical
• Molecule Type

 

Toll-Like Receptor 4 (TLR-4) Agonist Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Product Type

 

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Scope of the Toll-Like Receptor 4 (TLR-4) Agonist Pipeline Report

• Coverage- Global
• Toll-Like Receptor 4 (TLR-4) Agonist Companies- Eisai, Akaza Bioscience, OPNT-003, GeNeuro, MN-166 (ibudilast), Orexo, and others.
• Toll-Like Receptor 4 (TLR-4) Agonist Therapies- P2PAR-100, SBT8230, RG 6115, TransCon TLR 7/8 agonist, NKTR-262, BNT411, BO112, PrEP-001, BDB001, Cobitolimod, Tilsotolimod, SD 101, Lefitolimod, Vesatolimod, Vidutolimod, Rintatolimod, DUET 01, NJB 834, INNA 051, Glycopyranosyl lipid adjuvant, G 100, TARA-002, RO 7020531, Resiquimod,  BDC 1001, SHR 2150, LHC 165, PRX 034, ELI 002, IDX 9059, Entolimod, and others.
• Toll-Like Receptor 4 (TLR-4) Agonist Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Toll-Like Receptor 4 (TLR-4) Agonist Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

 

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Table of Content

1. Introduction
2. Executive Summary
3. Toll-Like Receptor 4 (TLR-4) Agonist: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Toll-Like Receptor 4 (TLR-4) Agonist– DelveInsight’s Analytical Perspective
7. In-depth Commercial Assessment
8. Toll-Like Receptor 4 (TLR-4) Agonist Collaboration Deals
9. Late Stage Products (Phase III)
10. E5564: Eisai
11. Drug profiles in the detailed report…..
12. Mid Stage Products (Phase II)
13. TAK-242: Akaza Bioscience
14. Drug profiles in the detailed report…..
15. Early Stage Products (Phase I)
16. OX125: Orexo
17. Drug profiles in the detailed report…..
18. Preclinical and Discovery Stage Products
19. Drug Name: Company Name
20. Drug profiles in the detailed report…..
21. Inactive Products
22. Toll-Like Receptor 4 (TLR-4) Agonist Key Companies
23. Toll-Like Receptor 4 (TLR-4) Agonist Key Products
24. Toll-Like Receptor 4 (TLR-4) Agonist- Unmet Needs
25. Toll-Like Receptor 4 (TLR-4) Agonist- Market Drivers and Barriers
26. Toll-Like Receptor 4 (TLR-4) Agonist- Future Perspectives and Conclusion
27. Toll-Like Receptor 4 (TLR-4) Agonist Analyst Views
28. Toll-Like Receptor 4 (TLR-4) Agonist Key Companies
29. Appendix

 

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